Protein antigens are no able to induce an immune response without being previously processed by antigen presenting cells (APCs). Following their processing that comprises their splitting to smaller fragments – peptides, APs subsequently present them to T cells; moreover, they activate them and polarise to a specific biological functions. Depending of antigen origin, there are two presentation pathways, exogenous and endogenous. Antigens originated from outside of APC, e.g. bacterial toxins, enzymes, etc., are presented by exogenous pathway and presented molecules are class II HLA molecules. T cell, that recognise presented peptides belong to helper subset of T cells. Antigens originated in the cytosol, such as antigens that appear in the cytoplasm of virus infected cells, are presented by endogenous pathway and presented molecules belong to class I HL-A molecules. T cells, that recognise presented peptides, represent cytotoxic T cells.
Antibodies. B cells
..bodies are molecules of glycoprotein nature that.. .. antigens either soluble or bound in membranes of cells in a specific way. They are present in plasma.. ..bodies are produced by B lymphocytes and.. .. by B lymphocytes and especially by plasma cells. B cells are born in the marrow and settle.. .. cells are not unique population, three distinct subsets are.. ..keywords: bodies, immunoglobulins, B cells, plasma.. ..keywords: immunoglobulins, B cells, plasma.. .. MUDr. Milan Buc, DrSc. Attachments: Attachment .. .. sensitive [?] Licence Antibodies. B cells | 28.2.2012 5.99 MB registered..
B lymphocytes and plasma cells
..B lymphocytes are principal cells that mediate.. .. lymphocytes are principal cells that mediate humoral adaptive immunity. After.. .. or to memory cells. Key words: B cells, subsets of B cells, memory B cells, plasma.. ..B lymphocytes are principal cells that mediate.. .. lymphocytes are principal cells that mediate humoral adaptive immunity. They.. .. of cells; they can be subdivided to three subsets: follicular B lymphocytes, B1 B lymphocytes.. ..keywords: B cells, B cell subsets, memory B cells, plasma.. ..keywords: cells, B cell subsets, memory B cells, plasma.. ..keywords: cells, B cell subsets, memory B cells, plasma.. .. MUDr. Milan Buc, DrSc. Prílohy: Príloha .. .. citlivé [?] Licencia B lymphocytes and plasma cells | 6.3.2017 7.32 MB MEFANET..
Type I hypersensitivity (Allergy)
.. I hypersensitivity belongs to the most common disorder mediated by.. ..bodies belonging to IgE class mediate this type of.. .. IgE antibodies bind to Fc receptors on mast cells and basophils. When these cell-associated.. ..keywords: anaphylaxis, atopy, IgE antibodies,.. .. MUDr. Milan Buc, DrSc. Prílohy: Príloha ..
Ophthalmooncology - Eyelid Tumors
.. spite of being a small organ, the eyelids contain numerous.. .. eyelid skin is the thinnest in the body and lacks subcutaneous fat, but otherwise.. .. is mostly cuboidal and contains goblet cells. Melanocytes are scattered in the basal layer.. ..keywords: tumors, basal cell.. ..keywords: tumors, basal cell.. .. - Eyelid Tumors 25.3.2020 6.61 MB faculty member – Ophthalmooncology -..
Practicals in Immunology No.6: Methods used in Transplantation Immunology (HLA-Typing)
.. provides basic information on the HLA-complex and.. .. with focus on kidney and haematopoetic stem cell transplantations. Most important HLA-typing.. .. Immunology (HLA-Typing) | 24.5.2013 4.33 MB registered..
Cytokines. PAMPs and PRRs
.. are soluble peptides that induce activation, proliferation.. .. activation, proliferation and differentiation of cells of the immune system. Moreover, cytokines.. .. recognises an infinite variety of antigens by millions of cell-surface receptors. Instead,.. .. an infinite variety of antigens by millions of cell-surface receptors. Instead, the innate immune.. .. MUDr. Milan Buc, DrSc. Attachments: Attachment ..
Ophthalmooncology - Tumors of the Orbit
..bital tumors can be benign or malignant and arise.. ..Benign pediatric tumors are most commonly dermoid.. .. course of radiation therapy. Because meningioma cells infiltrate bone of the skull base, complete.. ..keywords: of the orbit, benign tumors, malignant.. ..keywords: of the orb.. .. Ophthalmooncology - Tumors of the Orbit 25.3.2020 7.69 MB faculty..
Foeto-maternal relationships. The immune system of newborns
.. immune tolerance. The immune system secures it by various mechanisms – special cells,.. .. secures it by various mechanisms – special cells, cytokines, HLA molecules, peripheral tolerance.. .. of pregnancy depends on three the most important biological events: implantation of a blastocyt,.. .. of a blastocyt, invasion of trophoblast cells into decidua and myometrium to enable them an.. .. the myometrium. T cells, those of Th2 and Treg subsets, respectively, down-regulated maternal immune.. ..keywords: Blastocyst, NK cells, HLA molecules, tolerance,.. ..keywords: NK cells, HLA molecules, tolerance, immune system of.. .. MUDr. Milan Buc, DrSc. Prílohy: Príloha ..
The complent system and its biological significance
..bodies manage to protect us against germs.. .. by phagocytes easier and more effective or by cell lysis. However, in this case, they need a help.. .. are synthesised at various sites throughout the body. Most of them are produced in the liver and.. .. lectin, and alternative. Except target cells lysis, the complement mediates also other.. ..keywords: bodies, complement, lysis of target cells, imune.. ..keywords: complement, lysis of target cells, imune complexes, deficiencies of .. .. MUDr. Milan Buc, DrSc. Attachments: Attachment ..
Autoimmunity and autoimmune disease
.. system instead of reacting against foreign and aberrant self-antigens can attack self-molecules... ..bsp; Immunologic tolerance is defined as.. .. activated, leading to immune responses, or the cells may be inactivated or eliminated, leading to.. ..keywords: T cells, B cells, antibodies, genes, therapy,.. ..keywords: T cells, B cells, antibodies, genes, therapy,.. .. MUDr. Milan Buc, DrSc. Prílohy: Príloha ..