Prof. MUDr. Miroslav Mikulecký, mefanet(at)fmed.uniba.sk
Incidence of toxocarosis in Slovakia 1977-1990 showed an exponential increase with an accessory cycling, having 7-8 years period length.
Annual incidence rates of 3157 cases of leptospiroses recorded within 1949 and 2004, caused by the main serovars ificant or borderly significant periodicities, resembling those known from solar and geomagnetic activity, were identified. By comparing them with the time course of Wolf numbers, an almost exact reciprocity of maxima and minima of Wolf numbers and leptospiroses was disclosed. It is hypothetized that the epizoonotic character of these diseases supports the putative dependence of its manifestation upon the nature including the sun. Surprisingly, no similar results were found, so far, in the world scientific registers.
Russian scientist Tchijevskij investigated almost 100 years ago (suggested for Nobel prize) relationships between solar activity, cycling with the period around 11 years, and the status of mankind. He found „social excitation“, as revolutions and wars, at the time of solar maxima and peaceful activities like flourishing of arts at minima.The present paper explores whether such a parallelism applies also to the 500 years´ (semimillenial) cycling of solar activity. The present author obtained, using the cosinor analysis, significant positive anwer. It is hypothesized that one of the responsible factors could be solar impact on geomagnetic field.
From the descriptive towards inferential statistics: Hundred years since conception of the Student´s t-distribution
The 100th anniversary of the Student´s statistical t-distribution is commemorated.
The monthly registered Wolf numbers (i.e the numbers of sunspots), solar flares index and Ap index of the geomagnetic activity values display negative regression dependence („negatively correlate“) upon the monthly observed numbers of new cases of cerebral infarction.This phenomenon is present with delays from -6 months (infarction before the cosmogeophysical measurement) up to + 17 months (infarction after the cosmogeophysical measurement),with the most pronounced relationship for delay of +5 months.
Distinct increase in the incidence of this disease, observed in Central and Eastern Europe recently, was registered also in Slovak children. Nevertheless, an original finding is the significant presence of 10-11-years cycling, corresponding probably with that in the solar activity, and of 7-years cycling, known for geomagnetic activity These periodicities are superposed on an increasing linear trend, affirmed in some Western „main stream“ journals (e.g.Diabetologia) as the only pattern in this issue.
Circa- and ultradians in the occurrence of simple extrasystoles in healthy men at lowland in the light of inferential statistics
The 24-hour profile of hourly registered extrasystoles mean counts per one subjest in apparently healthy elderly males was studied with the aid of Halberg cosinor regression.
Rotor syndrome is a rare familial conjugated hyperbilirubinaemia with notmal liver histology and unknown cause. The hypothesis was tested that it can be an allele variant of Dubin-Johnson syndrome, caused by mutation in ABCC2 gene. The ABCC2 gene and protein were investigated in two patients with this syndrome. No sequence variations were found in 32 exons, adjacent intronic regions and the promoter region of ABCC2. Accordingly, Rotor syndrome is not an allelic variant of ABCC2 deficiency.