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Autoimmunity and autoimmune disease

Autoimmunity and autoimmune disease

The principal role of the immune system is to protect the organism from principally two the most dangerous events potentially threatening our life, i.e. infection and malignancy. However, sometimes the immune system instead of reacting against foreign and aberrant self-antigens can attack self-molecules. This inappropriate response of the immune system against self-components is termed autoimmunity.
There are 70 - 80 autoimmune disorders known till now and app. 5% of Caucasoid population suffers from them. Our understanding of autoimmunity has improved greatly during the last two decades, mainly because of the development of a variety of animal models of these diseases and the identification of genes that may predispose to autoimmunity. Nevertheless, the aetiology of most human autoimmune diseases remains still obscure.
The term “autoimmunity” is often erroneously used for a disease in which immune reactions accompany tissue injury; they are “a by-product” of a release of self-antigens to circulation without causing any damage; moreover, these “autoimmune reactions” help to degrade them and to remove them from the body.

author: Milan Buc | discipline: Immunology, Allergology | viewed: 3516x | published on: 9.4.2013 | last modified on: 13.5.2013

Foeto-maternal relationships. The immune system of newborns

Foeto-maternal relationships. The immune system of newborns

A success of pregnancy depends on a proper implantation and induction of immune tolerance. The immune system secures it by various mechanisms – special cells, cytokines, HLA molecules, peripheral tolerance take part in.

The immune system of the newborn has also its own specifics as it matures relatively long time till it reaches the same protective ability as characteristic for adults.

author: Milan Buc | discipline: Immunology, Allergology | viewed: 2195x | published on: 9.5.2012 | last modified on: 9.5.2012

Immunodeficiencies. AIDS

Immunodeficiencies. AIDS

The lecture deals with primary and secondary immunodefeciencies. It gives an overview on general clinical manifestations and their divisions according to the type of the immune functions defects. Must of the lecture devotes to AIDS.     

author: Milan Buc | discipline: Immunology, Allergology | viewed: 2590x | published on: 3.5.2012 | last modified on: 3.5.2012

Type I hypersensitivity (Allergy)

Type I hypersensitivity (Allergy)

Type I hypersensitivity belongs to the most common disorder mediated by immune reactions; it affects app. more than 30% of all individuals in Caucasoid population. Type I hypersensitivity is commonly called allergy. It is characterised by rapid onset (hence the term immediate hypersensitivity), within minutes of antigen challenge, and results in conspicuous clinical symptoms.

author: Milan Buc | discipline: Immunology, Allergology | viewed: 2405x | published on: 4.4.2012 | last modified on: 4.4.2012

Some aspects of the epidemiology and prognosis of zoonotic toxocarosis

Incidence of toxocarosis in Slovakia 1977-1990 showed an exponential increase with an accessory cycling, having 7-8 years period length.                                                 

author: Miroslav Mikulecký, Miroslav Mikulecký ml., P. Dubinský, P. Ondrejka, A. Štefančíková | discipline: Epidemiology, Preventive Medicine, Hygiene | viewed: 1653x | published on: 28.3.2012 | last modified on: 2.4.2012

Half century of leptospiroses in Slovakia and the solar spots

Annual incidence rates of 3157 cases of leptospiroses recorded within 1949 and 2004, caused by the main serovars ificant or borderly significant periodicities, resembling those known from solar and geomagnetic activity, were identified. By comparing them with the time course of Wolf numbers, an almost exact reciprocity of maxima and minima of Wolf numbers and leptospiroses was disclosed. It is hypothetized that the epizoonotic character of these diseases supports the putative dependence of its manifestation upon the nature including the sun. Surprisingly, no similar results were found, so far, in the world scientific registers.

author: Miroslav Mikulecký | discipline: Epidemiology, Preventive Medicine, Hygiene, Infectology | viewed: 1806x | published on: 28.3.2012 | last modified on: 2.4.2012

Solar activity, revolutions and cultural prime in the history of mankind

Russian scientist Tchijevskij investigated almost 100 years ago (suggested for Nobel prize) relationships between solar activity, cycling with the period around 11 years, and the status of mankind. He found „social excitation“, as revolutions and wars, at the time of solar maxima and peaceful activities like flourishing of arts at minima.The present paper explores whether such a parallelism applies also to the 500 years´ (semimillenial) cycling of solar activity. The present author obtained, using the cosinor analysis, significant positive anwer. It is hypothesized that one of the responsible factors could be solar impact on geomagnetic field.

author: Miroslav Mikulecký | discipline: Psychiatry, Psychology, Sexology | viewed: 1878x | published on: 28.3.2012 | last modified on: 2.4.2012

From the descriptive towards inferential statistics: Hundred years since conception of the Student´s t-distribution

The 100th anniversary of the Student´s statistical t-distribution is commemorated.                                                                                                                                                                              

author: Miroslav Mikulecký, Peter G. Fedor-Freybergh | discipline: Biophysics | viewed: 1904x | published on: 28.3.2012 | last modified on: 28.3.2012

Cerebral infarction versus solar and geomagnetic activity: a cross-regression study

The monthly registered Wolf numbers (i.e the numbers of sunspots), solar flares index and Ap index of the geomagnetic activity values display negative regression dependence („negatively correlate“) upon the monthly observed numbers of new cases of cerebral infarction.This phenomenon is present with delays from -6 months (infarction before the cosmogeophysical measurement) up to + 17 months (infarction after the cosmogeophysical measurement),with the most pronounced relationship for delay of +5 months.

author: Miroslav Mikulecký, Jaroslav Střeštík | discipline: Neurology | viewed: 1290x | published on: 28.3.2012 | last modified on: 28.3.2012

Monthly incidence of childhood diabetes type 1 in Slovakia 1985-1998

Distinct increase in the incidence of this disease, observed in Central and Eastern Europe recently, was registered also in Slovak children. Nevertheless, an original finding is the significant presence of 10-11-years cycling, corresponding probably with that in the solar activity, and of 7-years cycling, known for geomagnetic activity These periodicities are superposed on an increasing linear trend, affirmed in some Western „main stream“ journals (e.g.Diabetologia) as the only pattern in this issue.

author: Miroslav Mikulecký, Dagmar Michalková | discipline: Diabetology, Dietetics | viewed: 1150x | published on: 28.3.2012 | last modified on: 28.3.2012
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