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Faculty of Medicine, Comenius University in Bratislava
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Rotor–type hyperbilirubinaemia has no defect in the canalicular bilirubin export pump

Rotor syndrome is a rare familial conjugated hyperbilirubinaemia with notmal liver histology and unknown cause. The hypothesis was tested that it can be an allele variant of Dubin-Johnson syndrome, caused by mutation in ABCC2 gene. The ABCC2 gene and protein were investigated in two patients with this syndrome. No sequence variations were found in 32 exons, adjacent intronic regions and the promoter region of ABCC2. Accordingly, Rotor syndrome is not an allelic variant of ABCC2 deficiency.

author: Miroslav Mikulecký, Martin Hřebíček, Tomáš, Jirásek, Hana Hartmannová, Lenka Nosková, Viktor Stránecký, Robert Ivánek, Stanislav Kmoch, Dita Cebecauerová, Libor Vítek, Iva Subhanová, Pavel Hozák, Milan Jirsa | discipline: Biology, Gastroenterology and Hepatology | viewed: 1451x | published on: 28.3.2012 | last modified on: 28.3.2012

Antigen presentation; T cell mediated immunity

Antigen presentation;  T cell mediated immunity

Protein antigens are no able to induce an immune response without being previously processed by antigen presenting cells (APCs). Following their processing that comprises their splitting to smaller fragments – peptides, APs subsequently present them to T cells; moreover, they activate them and polarise to a specific biological functions. Depending of antigen origin, there are two presentation pathways, exogenous and endogenous. Antigens originated from outside of APC, e.g. bacterial toxins, enzymes, etc., are presented by exogenous pathway and presented molecules are class II HLA molecules. T cell, that recognise presented peptides belong to helper subset of T cells. Antigens originated in the cytosol, such as antigens that appear in the cytoplasm of virus infected cells, are presented by endogenous pathway and presented molecules belong to class I HL-A molecules. T cells, that recognise presented peptides, represent cytotoxic T cells.


author: Milan Buc | discipline: Immunology, Allergology | viewed: 1758x | published on: 28.3.2012 | last modified on: 28.3.2012

Phagocytosis. Inflammation

Phagocytosis. Inflammation

Phagocytosis is a process of bacteria engulfment and their killing. The phagocytic cells of mammals belong to two complementary systems, the myeloid and mononuclear-phagocytic systems. The myeloid system consists of cells that phagocyte rapidly, however they are not able of sustained effort. Tthey are represented by neutrophils and eosinophils. In contrast, cells of the mononuclear-phagocytic system act more slowly but are capable of repeated phagocytosis. Mmonocytes and macrophages are principal cell responsible for. Process of phagocytosis can be divided into several steps: chemotactic movement of phagocytes towards invading bacteria, opsonisation and recognition of bacteria by specific receptors, their engulfment and phagolysosome formation, bacteria killing and resolution. Bacteria can be killed by oxygen or nitrogen dependent mechanisms and by various antibacterial substances.

author: Milan Buc | discipline: Immunology, Allergology | viewed: 3053x | published on: 8.3.2012 | last modified on: 16.3.2012

SKULL (after Cunningham)

Cunningham Textbook of Anatomy (12th Edition, iss. 1981) provides the complete description of the separated skull bones, together with the description of the skull spaces and joints. This decription is suitable for the more detailed study of the skull then that offered by other recommended textbooks, enable students to be better prepared for the tests of Anatomy subject.

Suitable mainly for Dentistry branch students, but of course for the students of the General Medicine branch.

author: Zora Haviarová, Daniel John Cunningham, George John Romanes | discipline: Anatomy | viewed: 2332x | published on: 31.10.2011 | last modified on: 31.10.2011

Cysts of orofacial region

 Cysts of orofacial region.

author: Peter Stanko | discipline: Dentistry | viewed: 2124x | published on: 20.4.2011 | last modified on: 19.5.2011

Female internal genital organs

Female internal genital organs

Presentation guides so-named lecture, which provides the basic anatomical description of the female internal genital organs. It is dedicated for the medical students of the general medicine and dentistry branches.

author: Zora Haviarová | discipline: Anatomy | viewed: 4122x | published on: 18.1.2010 | last modified on: 25.5.2011

Male internal genital organs

Male internal genital organs

Presentation guides so named lecture, which provides the basic anatomical description of the male internal genital organs. It is dedicated for the medical faculty students of the general medicine and dentistry branches.

author: Zora Haviarová | discipline: Anatomy | viewed: 2709x | published on: 18.1.2010 | last modified on: 25.5.2011

Oral surgery

Oral surgery

Complete set of 22 topics from course „Oral surgery 1“ , which include 12 hours of lectures in summer semester in the 3rd class. The subject Oral surgery is divided in three courses within three semesters of study of Dentistry at the Faculty of medicine Comenius University in Bratislava and it is finished by oral exam at summer semester in the 4th class.

author: Peter Stanko, Daniela Novotňáková, Jozef Mikloš | discipline: Dentistry | viewed: 7201x | published on: 4.3.2009 | last modified on: 21.9.2016

Organic chemistry

Lecture from organic chemistry is designed for students of general medicine. The content of lecture represents the introduction to organic chemistry. Author of lecture introduces to students basic organic compouds, their structure and properties in relation to biologically important physiological and pathophysiological processes in the organism. Students will meet with these compounds and reactions during the study of metabolic transformation of compounds in biochemistry.

author: Zdeňka Ďuračková | discipline: Medical Chemistry and Biochemistry | viewed: 3166x | published on: 28.2.2009 | last modified on: 25.5.2011
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