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Autoimmunity and autoimmune disease

Autoimmunity and autoimmune disease

The principal role of the immune system is to protect the organism from principally two the most dangerous events potentially threatening our life, i.e. infection and malignancy. However, sometimes the immune system instead of reacting against foreign and aberrant self-antigens can attack self-molecules. This inappropriate response of the immune system against self-components is termed autoimmunity.
There are 70 - 80 autoimmune disorders known till now and app. 5% of Caucasoid population suffers from them. Our understanding of autoimmunity has improved greatly during the last two decades, mainly because of the development of a variety of animal models of these diseases and the identification of genes that may predispose to autoimmunity. Nevertheless, the aetiology of most human autoimmune diseases remains still obscure.
The term “autoimmunity” is often erroneously used for a disease in which immune reactions accompany tissue injury; they are “a by-product” of a release of self-antigens to circulation without causing any damage; moreover, these “autoimmune reactions” help to degrade them and to remove them from the body.

 
author: Milan Buc | discipline: Immunology, Allergology | viewed: 3281x | published on: 9.4.2013 | last modified on: 13.5.2013

Immunodeficiencies. AIDS

Immunodeficiencies. AIDS

The lecture deals with primary and secondary immunodefeciencies. It gives an overview on general clinical manifestations and their divisions according to the type of the immune functions defects. Must of the lecture devotes to AIDS.     

 
author: Milan Buc | discipline: Immunology, Allergology | viewed: 2313x | published on: 3.5.2012 | last modified on: 3.5.2012

Some aspects of the epidemiology and prognosis of zoonotic toxocarosis

Incidence of toxocarosis in Slovakia 1977-1990 showed an exponential increase with an accessory cycling, having 7-8 years period length.                                                 

 
author: Miroslav Mikulecký, Miroslav Mikulecký ml., P. Dubinský, P. Ondrejka, A. Štefančíková | discipline: Epidemiology, Preventive Medicine, Hygiene | viewed: 1581x | published on: 28.3.2012 | last modified on: 2.4.2012

Half century of leptospiroses in Slovakia and the solar spots

Annual incidence rates of 3157 cases of leptospiroses recorded within 1949 and 2004, caused by the main serovars ificant or borderly significant periodicities, resembling those known from solar and geomagnetic activity, were identified. By comparing them with the time course of Wolf numbers, an almost exact reciprocity of maxima and minima of Wolf numbers and leptospiroses was disclosed. It is hypothetized that the epizoonotic character of these diseases supports the putative dependence of its manifestation upon the nature including the sun. Surprisingly, no similar results were found, so far, in the world scientific registers.

 
author: Miroslav Mikulecký | discipline: Epidemiology, Preventive Medicine, Hygiene, Infectology | viewed: 1656x | published on: 28.3.2012 | last modified on: 2.4.2012

Solar activity, revolutions and cultural prime in the history of mankind

Russian scientist Tchijevskij investigated almost 100 years ago (suggested for Nobel prize) relationships between solar activity, cycling with the period around 11 years, and the status of mankind. He found „social excitation“, as revolutions and wars, at the time of solar maxima and peaceful activities like flourishing of arts at minima.The present paper explores whether such a parallelism applies also to the 500 years´ (semimillenial) cycling of solar activity. The present author obtained, using the cosinor analysis, significant positive anwer. It is hypothesized that one of the responsible factors could be solar impact on geomagnetic field.

 
author: Miroslav Mikulecký | discipline: Psychiatry, Psychology, Sexology | viewed: 1809x | published on: 28.3.2012 | last modified on: 2.4.2012

From the descriptive towards inferential statistics: Hundred years since conception of the Student´s t-distribution

The 100th anniversary of the Student´s statistical t-distribution is commemorated.                                                                                                                                                                              

 
author: Miroslav Mikulecký, Peter G. Fedor-Freybergh | discipline: Biophysics | viewed: 1837x | published on: 28.3.2012 | last modified on: 28.3.2012

Cerebral infarction versus solar and geomagnetic activity: a cross-regression study

The monthly registered Wolf numbers (i.e the numbers of sunspots), solar flares index and Ap index of the geomagnetic activity values display negative regression dependence („negatively correlate“) upon the monthly observed numbers of new cases of cerebral infarction.This phenomenon is present with delays from -6 months (infarction before the cosmogeophysical measurement) up to + 17 months (infarction after the cosmogeophysical measurement),with the most pronounced relationship for delay of +5 months.

 
author: Miroslav Mikulecký, Jaroslav Střeštík | discipline: Neurology | viewed: 1228x | published on: 28.3.2012 | last modified on: 28.3.2012

Monthly incidence of childhood diabetes type 1 in Slovakia 1985-1998

Distinct increase in the incidence of this disease, observed in Central and Eastern Europe recently, was registered also in Slovak children. Nevertheless, an original finding is the significant presence of 10-11-years cycling, corresponding probably with that in the solar activity, and of 7-years cycling, known for geomagnetic activity These periodicities are superposed on an increasing linear trend, affirmed in some Western „main stream“ journals (e.g.Diabetologia) as the only pattern in this issue.

 
author: Miroslav Mikulecký, Dagmar Michalková | discipline: Diabetology, Dietetics | viewed: 1092x | published on: 28.3.2012 | last modified on: 28.3.2012

Time course of nontyphoid salmonellosis in Slovakia 1957-2008

Yearly numbers of new cases of this disease, collected over one half century,were processed by uncostomed biometrical tools – testing of randomness of the time sequence using Poisson and „contagious“ distributions, cosinor regression and crosscorrelation.The older experience of these authors – cycling of the daily numbers of cases during synodic lunar cycle – has been extended to the years´ scales: cycling contemporal with the Moon nutation period was found as significant. It is another evidence for a putative effect of gravity on bacterial virulence of Salmonella. In the mean time, experiments in NASA laboratories,USA found a dangerous increase of Salmonella virulence in microgravity conditions. Practical consequencies for the medical securing of space flight crews are indicated.

 
author: Miroslav Mikulecký, Miroslav Mikulecký ml. | discipline: Epidemiology, Preventive Medicine, Hygiene, Infectology | viewed: 1065x | published on: 28.3.2012 | last modified on: 28.3.2012

Circa- and ultradians in the occurrence of simple extrasystoles in healthy men at lowland in the light of inferential statistics

The 24-hour profile of hourly registered extrasystoles mean counts per one subjest in apparently healthy elderly males was studied with the aid of Halberg cosinor regression.

 
author: Miroslav Mikulecký, Štefan Kujaník | discipline: Cardiology, Angiology | viewed: 1358x | published on: 28.3.2012 | last modified on: 28.3.2012
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