Ophthalmooncology - Pigmented Conjunctival Lesions

Conjunctival melanocytic lesions are the most common tumors of the conjunctiva, comprising 52% of all conjunctival tumors. Several classifications have been suggested for conjunctival melanocytic lesions. Thus far, the 1980 World Health Organization (WHO) classification has been most widely used and includes three pathologic categories: conjunctival nevus, conjunctival melanosis, and malignant melanoma (MM). 

Conjunctival nevus is further histologically classified into three types by its location relative to the surface epithelium: compound, junctional, and subepithelial nevus. Recently, IARC (International Agency for Research on Cancer) introduced the 2018 WHO classification of tumours of the eye. Based on this new classification, melanocytic tumors of the conjunctiva are categorized into conjunctival nevus (junctional, compound, and subepithelial), conjunctival melanocytic intraepithelial neoplasia (C-MIN) that include primary acquired melanosis (PAM) with and without atypia, conjunctival melanoma, and others (benign epithelial melanoses of the conjunctiva, inflamed juvenile conjunctival nevus, blue nevus, Spitz or spindle cell nevus).

The compound nevus is the most common type of conjunctival melanocytic tumors and has a benign course which does not require treatment. On the contrary, conjunctival MM is rare and carries serious consequences such as destruction of ocular tissues, distant metastasis (25%), and mortality (13–30%).

Given these wide variations in disease course, clinical distinction among conjunctival melanocytic lesions is essential to determine appropriate management of the lesion Importantly, the prevalence and prognosis of nevus and melanoma vary considerably among different racial/ethnic groups and geographic regions. However, most of studies on conjunctival melanocytic lesions have been performed in Caucasian populations.

Presentation ppt of pigmented epibulbar lesions for General Medicine stidents and Stomatology students also. 

 

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 Ophthalmooncology - Pigmented Conjunctival Lesions 25.3.2020 3.31 MB anyone

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