The 24-hour profile of hourly registered extrasystoles mean counts per one subjest in apparently healthy elderly males was studied with the aid of Halberg cosinor regression.

Successive peaks and nadirs were present since morning to afternoon in supraventricular as well as in ventricular extrasystoles. For the latter, however, the dispersion was broader. Accordingly, only one significant morning peak (around 9 h am) was identified for ventricular extrasystoles while four significant peaks (6-7h am, 9h am, 12h am-1h pm, and 4-5h pm) were found in supraventricular extrasystoles. The population prediction is shown for 95% confidence and 95% tolerance as corresponding corridors accompanying the point estimate of the periodic approximating regression function. The tolerance corridor can be used in practice for evaluating individual findings in an elderly man.

Acta Physiologica Hungarica 95 (3), pp.321-329, 2005.

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